Novel crystal of benzodiazepine derivative

Details Novel crystal of benzodiazepine derivative Novel crystal of benzodiazepine derivative

C - Chemistry, Metallurgy

07

D

C07D 243/24 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2165548

This invention provides a form B crystal of (R)-1- [2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-tolyl)urea. The B form crystals of the present invention are produced by recrystallizing the compound from a mixed solvent of at least 1 volume of water and 5 volumes of an alcohol and have excellent filtration property and flowability, so that they can be handled markedly easily at the time of filtration for their large scale production or when they are made into pharmaceutical preparations and therefore are useful in view of their industrial production.

Cristal du type B de (R)-1-[2,3-dihydro-1-(2'-méthylphénacyl)-2-oxo-5-phényl-1H-1,4-benzodiazépin-3-yl]-3-(3-tolyl)urée, qu'on produit en effectuant la recristallisation dans un mélange solvant composé de 5 parties en volume d'alcool et d'au moins 1 partie en volume d'eau. Sa filtrabilité et sa fluidité sont si bonnes qu'il est extrêmement facile à filtrer lors de sa production en masse et à manipuler dans la production d'une préparation pharmaceutique dans laquelle il est inclus, étant ainsi utile dans la production industrielle de ladite préparation.

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