C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2137665
Crystal D or E of 1-hydroxy-2-(imidazo[1,2-a]pyridin- 3-yl)ethane-1,1-bis(phosphonic acid) monohydrate having specified lattice spacing and relative intensity in the powder X-ray diffraction spectrum obtained by using Cu-K.alpha. radiation and a dehydration peak temperature of 135 to 149°C or 160 to 170°C according to TG-DSC thermogravimetric analysis; and to a solid pharmaceutical preparation containing the same. The crystals are useful for producing a stable solid pharmaceutical preparation of the above compound which has an excellent drug efficacy for diseases wherein increased bone resorption participates, such as osteoporosis.
Hamada Mamoru
Isomura Yasuo
Kaneko Yoshisaburo
Takeuchi Makoto
Yamamoto Noriya
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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