C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/496 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2671535
A novel crystalline form of 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-[(1-methylethyl)oxy]-N-1H-pyrazol-3-ylbenzamide is described in the specification. This compound is a glucokinase (GLK or GK) activator and useful as a pharmaceutical agent in the treatment or prevention of a disease or medical condition mediated through GLK, leading to a decreased glucose threshold for insulin secretion. Processes for the manufacture of the crystalline form, pharmaceutical compositions comprising the crystalline form and the use of the crystalline form in medical treatment are also described.
L'invention concerne un nouveau composé cristallin utile en tant qu'activateur de GLK. Une nouvelle forme cristalline de 3-{[5-(azétidin-1-ylcarbonyl) pyrazin-2-yl]oxy}-5-[(1-méthyléthyl) oxy]-N-1H-pyrazol-3-ylbenzamide est présentée dans la description. Ce composé est un activateur de glucokinase (GLK ou GK) et est utile en tant qu'agent pharmaceutique dans le traitement ou la prévention d'une maladie ou d'un état médical à médiation par GLK, conduisant à un seuil de glucose diminué pour la sécrétion de l'insuline. L'invention concerne également des procédés pour la fabrication de la forme cristalline, des compositions pharmaceutiques comprenant la forme cristalline et l'utilisation de la forme cristalline dans un traitement médical.
Mccabe James
Tomkinson Gary Peter
Astrazeneca Ab
Fetherstonhaugh & Co.
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