C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2694835
The present invention relates to a novel anhydrous crystalline form of zofenopril calcium of formula (I), chemically known as (4S)-1-[(2S)-3-(benzoylthio)-2-methylpropionyl]-4-(phenylthio)-L- proline calcium salt or hemi-calcium salt. The present invention further relates to a process for the preparation of the new crystalline form of zofenopril calcium, its use in pharmaceutical compositions and the use of the new crystalline form and compositions in the treatment of hypertension and various other diseases.
La présente invention porte sur une nouvelle forme cristalline anhydre du zofénopril calcique de formule (I), dont le nom chimique est le sel calcium ou le sel hémi-calcique de (4S)-1-[(2S)-3-(benzoylthio)-2-méthylpropionyl]-4-(phénylthio)-L-proline. La présente invention porte en outre sur un procédé de préparation de la nouvelle forme cristalline de zofénopril calcique, sur son utilisation dans des compositions pharmaceutiques, et sur l'utilisation de la nouvelle forme cristalline et des compositions dans le traitement de l'hypertension et de diverses autres maladies.
Generics [uk] Limited
Osler Hoskin & Harcourt Llp
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