C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/69 (2006.01) A61K 31/506 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2703230
The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patientssuffering from endothelin receptor mediated disorders, for example,cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris.
La présente invention concerne de nouvelles formes cristallines de bosentan ainsi que leurs procédés de préparation. L'invention concerne également des compositions pharmaceutiques comprenant lesdites formes cristallines ainsi que l'utilisation de ces compositions dans le traitement de patients souffrant de troubles médiés par les récepteurs de l'endothéline, et notamment de troubles cardiovasculaires tels que l'hypertension, l'hypertension pulmonaire, l'ischémie, le vasospasme et l'angine de poitrine.
Bansode Prakash
Gaitonde Abhay
Manojkumar Bindu
Mekde Sandeep
Phadtare Sunanda
Generics [uk] Limited
Osler Hoskin & Harcourt Llp
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