C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/08 (2006.01) A61K 31/4196 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2745882
Novel crystalline salts of 3-[4-(3-ethanesulfonyl-propyl)- bicyclo [2.2.2] oct-1-yl]-4-methyl-5 -(2-trifluoromethyl-phenyl) -4H-1,2,4-triazole are potent inhibitors of 110-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment.
L'invention porte sur de nouveaux sels cristallins du 3-[4-(3-éthanesulfonyl-propyl)-bicyclo[2.2.2]oct-1-yl]-4-méthyl-5-(2-trifluorométhyl-phényl)-4H-1,2,4-triazole qui sont de puissants inhibiteurs de la 11ß-hydrxystéroïde déshydrogénase de type 1 et sont utiles pour le traitement d'états pathologiques associés au syndrome métabolique ainsi qu'à un trouble cognitif. L'invention porte également sur des compositions pharmaceutiques contenant ces nouveaux sels, sur des procédés de préparation de ces sels et de leurs compositions pharmaceutiques, ainsi que sur leurs utilisations pour le traitement du diabète de type 2, de l'hyperglycémie, de l'obésité, de la dyslipidémie, de l'hypertension et d'un trouble cognitif.
Bereznitski Yuri V.
Ferlita Russell R.
Leazer John L. Jr.
Liu Jinchu
Lynch Joseph E.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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