Novel crystalline forms of the anti-cancer compound zd1839

Details Novel crystalline forms of the anti-cancer compound zd1839 Novel crystalline forms of the anti-cancer compound zd1839

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2702297

The invention concerns certain crystalline solvates and hydrates of the compound of the Formula (I) (see formula I) which is known inter alia by way of the code number ZD1839. In particular, the invention concerns a first solvate that occurs in the presence of methanol which is designated as Form 2 ZD1839 MeOH solvate, a second solvate that occurs in the presence of dimethyl sulphoxide which is designated as Form 3 ZD1839 DMSO solvate and a trihydrate that occurs in the presence of water which is designated Form 5 ZD1839 trihydrate. The invention further concerns processes for the preparation of these solvates and the trihydrate and for their conversion back to the compound ZD1839, pharmaceutical compositions containing them and their use in the manufacture of medicaments for use in the production of an anti-proliferative effect in a warm-blooded animal such as man.

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