Novel cxcl8 antagonists

Details Novel cxcl8 antagonists Novel cxcl8 antagonists

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 31/713 (2006.01) A61K 38/20 (2006.01) C12N 15/24 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2534828

Novel antagonists of the chemokine CXCL8 (also known as Interleukin-8) can be obtained by generating mutants having specific combinations of non- .conservative substitutions of basic amino acids located in the C-terminal region. Compounds prepared in accordance with the present invention can be used to block CXCL8 activity in vivo, thereby providing therapeutic compositions for use in the treatment or prevention of CXCL-8-related diseases.

L'invention concerne de nouveaux antagonistes de la chimiokine CXCL8 (également connue sous le nom d'interleukine 8) qui peuvent être obtenus par génération de mutants présentant des combinaisons spécifiques de substitutions non conservatrices d'acides aminés de base situés dans la région C-terminale. Les composés préparés selon l'invention peuvent être utilisés pour bloquer l'activité de la CXCL8 in vivo de façon à produire des compositions thérapeutiques destinées à être utilisées en traitement ou prévention de maladies associées à la CXCL8.

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