Novel cyano-substituted dihydropyrimidine compounds and...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 9/14 (2006.01) C07D 211/90 (2006.01) C07D 239/22 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 409/10 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2442482

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof.The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents.The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.

La présente invention concerne des composés représentés par la formule (I) et des sels pharmaceutiquement acceptables de ces composés. Ces composés de formule (I) induisent un arrêt mitotique, ce qui les rend utiles en tant qu'agents anti-cancéreux. Ces composés conviennent également pour d'autres maladies pouvant être traitées par déclenchement d'un arrêt mitotique.

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