C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/02 (2006.01) A61K 31/47 (2006.01) A61K 31/695 (2006.01) C07C 229/44 (2006.01) C07C 237/30 (2006.01) C07C 255/58 (2006.01) C07C 311/21 (2006.01) C07C 317/48 (2006.01) C07C 323/63 (2006.01) C07C 331/14 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 215/18 (2006.01) C07D 215/36 (2006.01) C07D 215/40 (2006.01) C07D 215/48 (2006.01) C07D 498/06 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2085347
The present invention provides novel cyclic amino- phenylacetic acid derivatives having modulating action on immune response, their optical isomers, their salts and their preparative processes, and therapeutic agents for autoimmune diseases containing them as effective ingredients, the cyclic aminophenylacetic acid derivatives being represented by a general formula (1) Image [wherein R and R1 each independently denotes hydrogen atom or lower alkyl group having 1 to 3 carbon atoms, R2 denotes a phenyl group (which may be substituted with 1 to 3 groups of halogen atom, methoxy group or their combinations) or trifluoromethyl group, and X denotes a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, cyano group, thiocyano group, trimethylsilylethinyl group, phenyl group (which may be substituted with halogen atom, methoxy group, methyl group or their combinations), carbamoyl group, carboxyl group, lower alkoxycarbonyl group having 1 to 3 carbon atoms, acetyl group, benzoyl group, nitro group, amino group, lower alkanoylamino group having 1 to 3 carbon atoms, benzoylamino group which may -71- be substituted, phenylsulfonylamino group which may be substituted, lower alkylthio group having 1 to 3 carbon atoms, lower alkylsulfinyl group having 1 to 3 carbon atoms, lower alkylsulfonyl group having 1 to 3 carbon atoms or halogen atom]. -72-
Awano Katsuya
Ishizaki Takayoshi
Kohno Yasushi
Kojima Eisuke
Kudoh Shinji
Borden Ladner Gervais Llp
Kyorin Pharmaceutical Co. Ltd.
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