C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/26 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61P 3/10 (2006.01) C07D 235/28 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2737694
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
L'invention concerne de nouveaux composés de formule structurale (I), qui sont des activateurs de la protéine kinase AMP et qui sont utiles pour le traitement, la prévention et la suppression de maladies médiées par l'AMPK (protéine kinase activée). Les composés de la présente invention sont utiles dans le traitement du diabète de type 2, de l'hyperglycémie, du syndrome métabolique, de l'obésité, de l'hypercholestérolémie et de l'hypertension.
Bao Jianming
Bookser Brett C.
Chung de Michael
Dang Qun
Gibson Tony S.
Merck Sharp & Dohme Corp.
Metabasis Therapeutics Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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