C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6558 (2006.01) A61K 31/675 (2006.01) A61P 3/00 (2006.01) C07F 9/6506 (2006.01)
Patent
CA 2741672
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
L'invention porte sur de nouveaux composés présentant la formule structurelle (I), qui sont des activateurs de la kinase de protéine AMP et qui sont utiles dans le traitement, la prévention et la suppression d'une maladie ayant pour médiateur la kinase de protéine activée par AMPK. Les composés selon la présente invention sont utiles dans le traitement du diabète de type 2, de l'hyperglycémie, du syndrome métabolique, de l'obésité, de l'hypercholestérolémie et de l'hypertension.
Bao Jianming
Cashion Daniel K.
Chung de Michael
Dang Qun
Gibson Tony S.
Merck Sharp & Dohme Corp.
Metabasis Therapeutics Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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