C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6506 (2006.01) A61K 31/675 (2006.01) A61P 3/00 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2741125
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
L'invention concerne de nouveaux composés de formule structurale (I) qui sont des activateurs d'AMP-protéine kinase et qui sont utiles dans le traitement, la prévention et la suppression de maladies médiées par la protéine kinase activée par l'AMPK. Les composés de la présente invention sont utiles dans le traitement du diabète type 2, de l'hyperglycémie, du syndrome métabolique, de l'obésité, de l'hypercholestérolémie et de l'hypertension.
Bao Jianming
Bookser Brett C.
Chung de Michael
Dang Qun
Gibson Tony S.
Merck Sharp & Dohme Corp.
Metabasis Therapeutics Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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