C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/73 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/54 (2006.01) A61P 9/10 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 213/82 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2555712
A novel cyclic compound having a 4-pyridylalkylthio group having an (un)substituted amino group introduced therein or a salt of the compound. They are useful as a medicine. The cyclic compound is a compound represented by the following formula [I], which is useful for the treatment of diseases in which angiogenesis participates. In the following formula [I], ring A represents a benzene ring or a 5- or 6-membered aromatic heterocycle optionally fused with a cycloalkane ring; B represents alkylene; R1 and R2 each represents H, (substituted) aryl, (substituted) heterocyclic group, etc.; R3 and R4 each represents H, (substituted) alkyl, (substituted) cycloalkyl, -Z-R5, etc.; R5 represents (substituted) alkyl, (substituted) aryl, (substituted) heterocyclic group, etc.; X and Y each represents H, etc.; Z represents -CO-, -COO-, -CONR6- , -SO2-, etc.; R6 represents H, etc.; p is 0, 1, or 2; and q is 0 or 1.
L'invention porte sur: un nouveau composé cyclique présentant un groupe 4-pyridylalkylthio comportant un groupe amino (non) substitué introduit; et sur un sel dudit composé, tous deux à usage médical. Le composé cyclique, de formule (I) s'utilise pour le traitement de maladies angiogènes. Dans ladite formule (I): A représente un cycle benzénique ou un hétérocycle aromatique à 5- ou 6- membres facultativement fusionné avec un cycle cycloalkane; B représente alkylène; R<1> et R<2> représentent chacun H, aryle (substitué), un groupe hétérocyclique (substitué), etc.; R<3> et R<4> représentent chacun H, alkyle (substitué), cycloalkyle (substitué), -Z-R<5>, etc.; R<5> représente alkyle (substitué), aryle (substitué), un groupe hétérocyclique (substitué), etc.; X et Y représentent chacun H, etc.; Z représente -CO-, -COO-, -CONR<6>-, -SO2-, etc.; R<6> représente H, etc.; p est 0, 1, ou 2; et q est 0 ou 1.
Honda Takahiro
Inaba Takaaki
Kawashima Kenji
Okamoto Kazuyoshi
Tajima Hisashi
Fetherstonhaugh & Co.
Santen Pharmaceutical Co. Ltd.
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