Novel cyclic phosphate diesters of 1,3-propane-1-aryl diols...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/6574 (2006.01) A61K 31/7052 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2503729

Compounds of Formula (I), their preparation and synthetic intermediates, and their use in the synthesis of prodrugs; wherein: V and L are trans relative to one another; V is selected from group consisting of carbocyclic aryl, substituted carbocyclic aryl, heteroaryl, and substituted heteroaryl; and L is a leaving group selected from the group consisting of halogen, alkyl sulfonate, aryloxy optionally substituted with 1-2 substituents, N-containing heteroaryl, and N-hydroxy-nitrogen containing heteroaryl; and salts thereof.

L'invention concerne des composés de formule (I), leur préparation, leurs intermédiaires synthétiques, et leur utilisation dans la synthèse de promédicaments. Dans ladite formule, V et L sonttrans l'un relativement à l'autre; V est sélectionné dans le groupe constitué par aryle carbocyclique, aryle carbocyclique substitué, hétéroaryle et hétéroaryle substitué; et L est un groupe partant sélectionné dans le groupe constitué par halogène, sulfonate d'alkyle, aryloxy éventuellement substitué par 1 à 2 substituants, hétéroaryle contenant N, et hétéroaryle contenant N-hydroxy-azote. L'invention concerne également des sels desdits composés.

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