Novel cyclic tetrapeptide derivatives and pharmaceutical use...

Details Novel cyclic tetrapeptide derivatives and pharmaceutical use... Novel cyclic tetrapeptide derivatives and pharmaceutical use...

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) A61K 38/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2362817

Cyclic tetrapeptide derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof: (wherein R21 and R22 are each independently hydrogen, linear C1-C6 alkyl to which a nonaromatic cycloalkyl group or an optionally substituted aromatic ring may be bonded, or branched C3- C6 alkyl to which a nonaromatic cycloalkyl group or an optionally substituted aromatic ring may be bonded; and R1 and R3 are each independently linear C1-C5 alkylene which may have a C1-C6 side chain, and the side chain may form a fused ring structure on the alkylene chain). Histone deacetylase inhibitors, MHC class I molecule development promotors and drug compositions, containing as the active ingredient the above tetrapeptide derivatives or pharmaceutically acceptable salts thereof.

L'invention concerne des dérivés de tétrapeptides cycliques représentés par la formule générale (I), ou des sels pharmaceutiquement acceptables de ceux-ci. (Dans la formule, R¿21? et R¿22? sont chacun indépendamment hydrogène, alkyle en C¿1?-C¿6? linéaire auquel peut être lié un groupe cycloalkyle non aromatique ou un noyau aromatique éventuellement substitué, ou alkyle en C¿3?-C¿6? ramifié auquel peut être lié un groupe cycloalkyle non aromatique ou un noyau aromatique éventuellement substitué ; et R¿1? et R¿3? sont chacun indépendamment alkylène en C¿1?-C¿5? pouvant comporter une chaîne latérale en C¿1?-C¿6?, la chaîne latérale pouvant former une structure de noyau condensé sur la chaîne d'alkylène). L'invention concerne des inhibiteurs d'histone désacétylase, des promoteurs de développement de molécules du CMH de classe I et des compositions de médicaments qui contiennent comme principe actif lesdits dérivés de tétrapeptides ou des sels pharmaceutiquement acceptables de ceux-ci.

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