Novel cytokine zalphaii ligand

C - Chemistry – Metallurgy – 12 – N

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C12N 15/19 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2366921

The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells <i>in vitro</i> and <i>in vivo</i>. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

L'invention concerne des molécules polynucléotidiques et polypeptidiques du ligand zalpha11. Le ligand zalpha11 est une nouvelle cytokine. On peut utiliser ces polypeptides dans des procédés de stimulation de la prolifération et/ou du développement de cellules hématopoïétiques <i>in vitro</i> et <i>in vivo</i>. L'invention concerne également des procédés de production de cette protéine, des utilisations de celle-ci ainsi que des anticorps dirigées contre cette protéine.

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