C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 17/00 (2006.01) A61P 35/00 (2006.01) C07J 75/00 (2006.01)
Patent
CA 2454799
This invention relates to a group of novel sapogenins, their use in anti- cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM- 110 and PBM-100 (the dammarane sapogenin structure is specifically clean of any sugar moieties (glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarane sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained by chemical cleavage of dammarane saponins. The invention also includes a novel application of the said sapogenins for anti- cancer treatment by using them separately or together, and/or jointly with other drugs, as well as to the process of producing these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer effect when applied, particularly against multi-drug resistant cancers.
Cette invention porte sur un groupe de nouvelles sapogénines, sur leur utilisation dans des applications anticancéreuses et sur leur procédé de production. De manière plus spécifique, cette invention concerne un nouveau groupe de sapogénines dammaranes, à savoir PAM-120, PBM-110 et PBM-100 (la structure de sapogénine dammarane est spécifiquement exempte de fragments de sucre (glycones) quel que soit l'emplacement et d'hydroxyl à C-20) ainsi que PAN-20 et PAN-30 (la structure de sapogénine dammarane comporte des fragments de sucre mais est exempte d'hydroxyl à C-20), lequel groupe est obtenu par clivage chimique de saponines dammarane. Cette invention comprend également une nouvelle application de ces sapogénines pour un traitement anticancéreux consistant à les utiliser séparément ou ensemble, et/ou conjointement avec d'autres médicaments. Cette invention concerne également un procédé de production de ces nouvelles sapogénines. Ces nouvelles sapogénines dammarane présentent un effet anticancéreux surprenant lorsqu'elles sont utilisées, en particulier contre des cancers qui résistent aux antibiotiques.
Huang Dong
Qi Dong Feng
Oyen Wiggs Green & Mutala Llp
Panagin Pharmaceuticals Inc.
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