Novel dendritic polymers and their biomedical uses

C - Chemistry – Metallurgy – 08 – F

Patent

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C08F 26/06 (2006.01) A61B 17/04 (2006.01) A61F 2/02 (2006.01) A61F 9/007 (2006.01) A61K 9/70 (2006.01) A61K 45/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61L 15/22 (2006.01) A61L 15/58 (2006.01) A61L 24/04 (2006.01) A61L 27/14 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C08F 16/02 (2006.01) C08F 22/02 (2006.01) C08F 24/00 (2006.01) C08G 63/00 (2006.01) C08G 85/00 (2006.01) C08L 99/00 (2006.01)

Patent

CA 2438193

Novel dendritic polymers are employed to clinically seal or repair wounds and treat traumatized or degenerative tissue. Novel crosslinkable biopolymers such as dendritic macromolecules are used in vitro, in vivo and in situ to treat ophthalmological, orthopaedic, cardiovascular, plastic surgery, pulmonary or urinary wounds or injuries. The crosslinkable dendritic macromolecules can be fabricated into cell scaffold/gel/matrix of specified shapes and sizes using one-photon and multi-photon spectroscopic techniques. The crosslinked polymers can be seeded with cells and used to repair or replace organs, tissues or bones. Alternatively, the polymers and cells can be mixed and injected into the in vivo site and crosslinked in situ for organ, tissue or bone repair or replacement.

L'invention concerne de nouveaux dendrimères utilisés afin de colmater ou réparer cliniquement des blessures et traiter des tissus traumatisés ou dégénératifs. L'invention concerne également des nouveaux biopolymères réticulables, tels que des macromolécules dendritiques, utilisés in vitro, in vivo et in situ afin de traiter des blessures ou des lésions ophtalmologiques, orthopédiques, cardiovasculaires, de chirurgie plastique, pulmonaires ou urinaires. Les macromolécules dendritiques réticulables peuvent être fabriquées dans des matrice/gel/structure de cellule de formes et de tailles spécifiques au moyen de techniques spectroscopiques à un ou plusieurs photons. Les polymères réticulables peuvent être semés avec des cellules et utilisés en vue de réparer ou de remplacer des organes, des tissus ou des os. Dans un autre mode de réalisation, les polymères et les cellules peuvent être mélangés et injectés dans le site in vivo et réticulés in situ en vue de réparer ou de remplacer des organes, des tissus ou des os.

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