Novel deoxynucleoside kinase enzyme variants

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) A61K 31/711 (2006.01) A61K 38/45 (2006.01) C07K 14/46 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2408530

This invention relates to novel multi-substrate deoxyribonucleoside kinase variants. More specifically the invention provides novel deoxyribonucleoside kinase variants derived from insects or lower vertebrates, in particular from Drosophila melanogaster, from Bombyx mori, or from Xenopus laevis, novel polynucleotides encoding multi-substrate nucleoside kinase variants, vector constructs comprising the polynucleotide, host cells carrying the polynucleotide or vector, methods of sensitising cells to prodrugs, method of inhibiting pathogenic agents in warm-blooded animals, and pharmaceutical compositions comprising deoxyribonucleoside kinase variants of the invention.

L'invention concerne de nouvelles variantes de kinase désoxyribonucléoside multi-substrats. Plus particulièrement, l'invention porte sur de nouvelles variantes de kinase désoxyribonucléoside dérivées d'insectes ou de vertébrés inférieurs, notamment de <i>Drosophila melanogaster</i>, de <i>Bombyx mori</i>, ou de <i>Xenopus laevis</i>, de nouveaux polynucléotides codant pour des variantes de kinase nucléosidique multi-substrats, des constructions de vecteur comprenant le polynucléotide, des cellules hôtes transportant le polynucléotide ou le vecteur, des procédés de sensibilisation des cellules aux promédicaments, des procédés d'inhibition d'agent pathogènes dans des animaux à sang chaud, et des compositions pharmaceutiques comprenant des variantes de kinase désoxyribonucléoside de l'invention.

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