Novel deoxyribonuclease, gene encoding the same and use thereof

Details Novel deoxyribonuclease, gene encoding the same and use thereof Novel deoxyribonuclease, gene encoding the same and use thereof

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) A61K 31/195 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2346127

A novel acidic DNase (DLAD) which is an endonuclease capable of divalent cation-independently cleaving DNA under acidic conditions, sustaining its activity even in the acidic to neutral pH region and not inhibited by G-actin; a DNA encoding this enzyme; an expression vector containing this DNA; a host cell transformed by this expression vector; and medicinal compositions containing as the active ingredient the DLAD, the DLAD expression vector or the host cell transformed by the expression vector. These medicinal compositions are useful as remedies for cystic fibrosis as a substitute for DNase I and can provide a new approach to the prevention and treatment of infectious diseases.

L'invention concerne une nouvelle désoxyribonucléase acide (DLAD) qui est une endonucléase pouvant effectuer un clivage d'ADN, indépendamment des cations divalents, dans des conditions acides, maintenir son activité même dans une plage de pH acide à neutre et qui n'est pas inhibée par la g-actine; un ADN codant cette enzyme; un vecteur d'expression contenant cet ADN; une cellule hôte transformée par ce vecteur d'expression; et des compositions médicinales contenant, comme principe actif, la DLAD, le vecteur d'expression de DLAD ou la cellule hôte transformée par ce vecteur d'expression. Ces compositions médicinales s'utilisent comme remèdes pour la fibrose kystique, en tant que substitut à la désoxyribonucléase I, et permettent d'adopter une nouvelle approche pour prévenir et traiter les maladies infectieuses.

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