C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/027 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01) C07K 5/02 (2006.01) C07K 11/00 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2497281
A novel compound which is useful as a preventive or a remedy for diseases in which HDAC participates, in particular, tumor and cell proliferative diseases. A depsipeptide compound or its pharmaceutically acceptable salt has a favorable HDAC inhibitory effect and an activity of inhibiting the proliferation of human cancer cells and, therefore, is useful in treating and improving diseases and pathogenic conditions in which histone acetylation participates, in particular, tumor and cell proliferative diseases.
Cette invention se rapporte à un nouveau composé qui est utile comme agent prophylactique ou thérapeutique contre les maladies dans lesquelles l'histone désacétylase (HDAC) joue un rôle, notamment les maladies tumorales et les maladies de prolifération des cellules. Un composé dépsipeptide ou son sel acceptable sur le plan pharmaceutique ont un effet favorable d'inhibition de l'HDAC et une action inhibitrice sur la prolifération des cellules cancéreuses humaines et il sont par conséquent utiles pour traiter et atténuer les maladies et les états pathogènes dans lesquels l'acétylation de l'histone joue un rôle, notamment les maladies tumorales et les maladies de prolifération des cellules.
Amase Mitsuo
Amino Nobuaki
Mori Masamichi
Nagai Koji
Shindo Nobuaki
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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