C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/18 (2006.01) A61K 9/70 (2006.01) A61K 31/137 (2006.01) A61K 31/215 (2006.01) A61K 31/7034 (2006.01) A61P 21/00 (2006.01) C07C 219/28 (2006.01) C07C 271/08 (2006.01) C07C 271/44 (2006.01) C07C 271/52 (2006.01) C07C 307/02 (2006.01)
Patent
CA 2328920
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compouds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
L'invention concerne de nouveaux dérivés de 3,3-diphénylpropylamines, des procédés permettant de les préparer, des compositions pharmaceutiques contenant ces nouveaux composés et l'utilisation de ces composés pour la préparation de médicaments. L'invention concerne plus particulièrement de nouveaux précurseurs d'agents anti-muscariniques qui ont des propriétés pharmacocinétiques supérieures à celles des médicaments existants tels que l'oxybutynine et la toltérodine, un procédé de préparation de ces précurseurs, des compositions pharmaceutiques les contenant et un procédé d'utilisation de ces composés, ainsi que des compositions destinées au traitement de l'incontinence urinaire, de l'hyperactivité gastro-intestinale (syndrome du côlon irritable) et d'autres pathologies affectant la contractilité des muscles lisses.
Meese Claus
Sparf Bengt
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Schwarz Pharma Ag
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