C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/44 (2006.01) A61K 31/122 (2006.01) A61K 31/15 (2006.01) A61P 25/28 (2006.01) C07C 49/513 (2006.01)
Patent
CA 2576393
The invention relates to compounds of formula (I): where X + Y = keto, or X = OH and Y =H, or X + Y = oxime or methyloxime, B = OH and C + D =H, or C + D = C1-C4 linear or branched alkyl, or C = H and D = C1-C4 linear or branched alkyl, or B + C = keto and D = methyl, hydroxyl, or methylamino, or B and C = H and D = methylamino, or B + C = oxime and D = methyl and R = C1-C10 linear or branched alkyl, the salts, esters, or salts of esters thereof as medicament, in particular as neuroprotectors, novel compounds of formula (I) and pharmaceutical compositions.
Composé de formule (I) : X + Y = céto, ou X = OH et Y =H, ou X + Y = groupement oxime ou méthyloxime ; B = OH et C + D =H, ou C + D = radicaux alkyles linéaires ou ramifiés en C1-C4, ou C = H et D = radical alkyle linéaire ou ramifié en C1-C4 ; ou bien B + C = céto et D = méthyle, hydroxyle, ou méthyl aminé ; ou bien B et C = H et D = groupement méthyl aminé ; ou bien B + C = oxime et D = méthyle ; et R = alkyle linéaire ou ramifié en C1-C10 ; sels, esters et sels des esters, à titre de médicament, applications notamment comme neuroprotecteurs, nouveaux composés de formule (I) et compositions pharmaceutiques.
Bordet Thierry
Drouot Cyrille
Robic
Trophos
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