C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/64 (2006.01) A61K 31/195 (2006.01) C07C 205/26 (2006.01) C07C 205/37 (2006.01) C07C 205/59 (2006.01) C07C 229/70 (2006.01) C07C 255/59 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2156079
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, halogen and cyano; R3, R4 are the same or different and selected from halogen, methyl, fluoroalkyl, cyano and Z- R5 wherein Z is selected from CH n, NH m, O, S, SO2 and CO wherein nil or 2; m=0 or 1 and R5 is selected from alkyl, aryl and fluoroalkyl; or R3 and R4 together form a saturated or unsaturated ring system Y-V-Z wherein Y and Z, independently of each other, are as defined for Z above and V is selected from C1-C3 alkylene or alkenylene, -N=, -N=N- and (a), wherein R7=H or alkyl; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxy-anthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.
Bjork Susanna Karin Maria
Gotthammar Kristina Birgitta
Linderberg Mats Torbjorn
Luthman Per Johan
Persson Kerstin Margareta Irma
Aktiebolaget Astra
Fetherstonhaugh & Co.
The University Of Maryland
LandOfFree
Novel derivatives of 3-hydroxy anthranilic acid, methods and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel derivatives of 3-hydroxy anthranilic acid, methods and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel derivatives of 3-hydroxy anthranilic acid, methods and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2089150