C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/381 (2006.01) A61K 31/4188 (2006.01) A61P 9/10 (2006.01) C07D 209/00 (2006.01) C07D 235/00 (2006.01) C07D 277/00 (2006.01) C07D 277/04 (2006.01) C07D 277/34 (2006.01) C07D 311/58 (2006.01) C07D 417/12 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2492837
The invention relates to novel cycloalcanodione derivatives which are agonists of serotonin receptor subtype (5- hydroxytryptamine, 5-HT) 5-HT1A and which are hence useful in the treatment of pathological states for which an agonist of said receptors is indicated. Said derivatives are particularly useful as neuroprotective agents, more particularly in the treatment and prophylaxis of cerebral damage caused by ischemic or traumatic stroke. Said cycloalcanodione derivatives generally correspond to formula (I).
L'invention concerne de nouveaux dérivés de cycloalcanodiones qui sont agonistes du sous-type de récepteur de sérotonine (5-hydroxytryptamine, 5-HT) 5-HT¿1A? et qui, par conséquent, sont utiles dans le traitement d'états pathologiques pour lesquels un agoniste de ces récepteurs est indiqué. En particulier, ces dérivés sont utiles en tant qu'agents neuroprotecteurs, notamment dans le traitement et la profilaxe de la lésion cérébrale produite par l'ictus ischémique ou traumatique. De façon générale, ces dérivés de cycloalcanodione correspondent à la formule I.
Benhamu Salama Bellinda
Del Rio Zambrana Joaquin
Delgado Wallace Mercedes
Frechilla Manso Diana
Fuentes Cubero Jose Angel
Cepa Schwarz Pharma S.l.
Gowling Lafleur Henderson Llp
Schwarz Pharma S.l.
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