Novel dhsp90 inhibitory carbazole derivatives, compositions...

Details Novel dhsp90 inhibitory carbazole derivatives, compositions... Novel dhsp90 inhibitory carbazole derivatives, compositions...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 209/88 (2006.01) C07D 213/16 (2006.01) C07D 215/12 (2006.01) C07D 231/56 (2006.01) C07D 233/64 (2006.01) C07D 235/18 (2006.01) C07D 261/20 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 451/04 (2006.01) C07D 453/00 (2006.01) C07D 471/04 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2718488

The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R1; R is selected from the group comprising Formula (II) with R1 and/or R1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkythio, or carboxy that is free or esterified by an alkyl, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO-alkyl, sulfonamide, NH-SO2-alkyl, S(O)2-NHalkyl, or S(O2)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is O, S, NR2, C(O), S(O), or S(O)2; Z is optionally substituted H, HaI, -O-R2 or NH-R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs.

L'invention concerne les nouveaux produits de formule (I) dans lesquels Het représente un hétérocycle éventuellement substitué par un ou plusieurs radicaux R1 ou R'1, R est choisi dans le groupe constitué par (A'), (B), (C), (D) et (E) avec R1 et/ou R'1, choisis parmi H, halogène, CF3, nitro, cyano, alkyle, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, phénylalcoxy, alkylthio, carboxy libre ou estérifié par un radical alkyle, carboxamide, CO- NH(alkyl), CON(alkyl)2, NH-CO- alkyl, sulfonamide, NH-SO2-alkyl, S(O)2-NHalkyl, S(O2)-N(alkyl)2; tous ces radicaux éventuellement substitués; W1, W2, W3 représentent indépendemment CH ou N, X représente O, S, NR2, C(O), S(O) ou S(O)2; Z représente H, Hal, -O-R2 ou -NH-R2 avec R2 représente H, alkyle, cycloalkyle ou hétérocycloalkyle éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.

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