Novel diaminomethylidene derivative

Details Novel diaminomethylidene derivative Novel diaminomethylidene derivative

C - Chemistry, Metallurgy

07

D

C07D 265/30 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07C 229/30 (2006.01) C07C 255/30 (2006.01) C07C 275/40 (2006.01) C07D 211/34 (2006.01) C07D 241/04 (2006.01) C07D 265/34 (2006.01) C07D 279/12 (2006.01) C07D 295/13 (2006.01) C07D 295/145 (2006.01) C07D 451/04 (2006.01) C07D 471/08 (2006.01) C07D 498/08 (2006.01) C07D 513/08 (2006.01)

Patent

CA 2189964

A novel diaminomethylidene derivative respresented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R1 represents hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, etc.; R2 represents, for example, a group represented by any of general formulae (a), (b), (c), (d), (e) and (f); R3 represents hydrogen, C1-C6 alkyl, etc.; and X represents O, S, CHNO2, C(COOR4)2, C(COOR4)CN, C(CN)2, etc. This compound is useful as a gastrointestinal excitomotor for treating digestive diseases.

Cette invention se rapporte à un nouveau dérivé de diaminométhylidène, représenté par la formule générale (I), et à un sel de ce dérivé acceptable sur le plan pharmacologique. Dans cette formule (I), R?1¿ représente hydrogène, alkyle C¿1?-C¿6?, cycloalkyle C¿3?-C¿6?, etc.; R?2¿ représente par exemple un groupe représenté par n'importe laquelle des formules générales suivantes (a), (b), (c), (d), (e) et (f); R?3¿ représente hydrogène, alkyle C¿1?-C¿6?, etc.; et X représente O, S, CHNO¿2?, C(COOR?4¿)¿2?, C(COOR?4¿)CN, C(CN)¿2?, etc. Ce composé est utile comme excitomoteur gastro-intestinal pour traiter les maladies de l'appareil digestif.

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