Novel diarylamide derivatives and use thereof as medicines

Details Novel diarylamide derivatives and use thereof as medicines Novel diarylamide derivatives and use thereof as medicines

C - Chemistry, Metallurgy

07

C

C07C 271/28 (2006.01) A61K 31/245 (2006.01) A61K 31/341 (2006.01) A61K 31/351 (2006.01) A61K 31/357 (2006.01) A61K 31/36 (2006.01) A61K 31/366 (2006.01) A61K 31/381 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A61K 31/443 (2006.01) A61K 31/445 (2006.01) A61K 31/5375 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 17/00 (2006.01) A61P 43/00 (2006.01) C07C 237/22 (2006.01) C07C 271/60 (2006.01) C07C 275/34 (2006.01) C07C 275/42 (2006.01) C07C 335/22 (2006.01) C07D 211/

Patent

CA 2385972

Diarylamide derivatives represented by general formula (1) or salts thereof, and pharmaceutical compositions containing the derivatives or the salts as the active ingredient, wherein A and B are each an aromatic ring such as benzene ring; COY and NHCOX are adjacent to each other and bonded to carbon atoms constituting A; X is alkylene, alkyleneoxy, or a single bond; Y is alkyl, alkoxy, hydroxyl, or optionally substituted amino; R1 is hydrogen, halogeno, hydroxyl, alkyl, or the like, with the proviso that when A is a benzene ring, R1 is not hydrogen; R2 is hydrogen, halogeno, hydroxyl, alkyl, or the like; R3 and R4 are each optionally substituted imino, oxygen, or a single bond; R5 is alkyl, optionally substituted phenyl, or the like; and Z is oxygen or sulfur.

Cette invention se rapporte à des dérivés de diarylamide, représentés par la formule générale (I), ou à des sels de ces dérivés; ainsi qu'à des compositions pharmaceutiques contenant ces dérivés ou ces sels comme principe actif. Dans cette formule (I), A et B représentent chacun un cycle aromatique, tel qu'un cycle benzène; COY et NHCOX sont adjacents l'un à l'autre et sont liés aux atomes de carbone constituant A; X représente alkylène, alkylénoxy ou une liaison simple; Y représente alkyle, alcoxy, hydroxyle ou amino éventuellement substitué; R?1¿ représente hydrogène, halogéno, hydroxyle, alkyle ou similaire, à condition que, lorsque A représente un cycle benzène, alors R?1¿ ne représente pas hydrogène; R?2¿ représente hydrogène, halogéno, hydroxyle, alkyle ou similaire; R?3¿ et R?4¿ représentent chacun imino éventuellement substitué, oxygène ou une liaison simple; R?5¿ représente alkyle, phényle éventuellement substitué, ou similaire; et Z représente oxygène ou soufre.

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