C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61K 31/37 (2006.01) C07C 307/02 (2006.01) C07C 311/29 (2006.01) C07C 323/22 (2006.01) C07D 215/02 (2006.01) C07D 215/36 (2006.01) C07D 215/58 (2006.01)
Patent
CA 2303429
In accordance with the present invention, there is now provided novel anti-HIV compounds of formulae selected from the group consisting of: (I), (II), (III), (IV) and (V) wherein R1 is hydrogen or C1-C4 alkyl; R2 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy or halogen; R3 is hydrogen, hydroxy, C1-C4 alkyl, C1-C4 alkoxy or halogen; R4 is hydrogen or halogen; R5 is hydrogen; C1-C4 alkoxy, nitro, halogen or haloalkyl; R6 is hydrogen or nitro; R7 is hydrogen or C1-C4 alkyl, C1-C4 alkoxy, nitro or halogen; R8 is hydrogen, hydroxy, C1-C4 alkyl, C1-C4 alkoxy or halogen; R9 is hydrogen or nitro; R10 is hydrogen or halogen; R11 is hydrogen, C1-C4 amin; R12 is hydrogen, C1-C4 alkyl or halogen; R13 is hydrogen, C1-C4 amin; R14 is hydrogen or halogen; R15 is hydrogen, C1-C4 alkoxy, C1-C4 haloalkyl, nitro, or halogen; R16 is hydrogen or nitro; R17 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, nitro or halogen; R18 is hydrogen, C1-C4 alkoxy, hydroxy, or halogen; R19 is hydrogen or nitro; R20 is hydrogen or halogen, and R21 is hydrogen or NO2 or a pharmaceutically acceptable salt thereof.
Cette invention se rapporte à de nouveaux composés anti-VIH, représentés par l'une des formules (I), (II), (III), (IV) et (V), ou à un sel pharmaceutiquement acceptable de ces composés. Dans les formules susmentionnées, R¿1? est hydrogène ou alkyle C¿1?-C¿4?; R¿2? est hydrogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4? ou halogène; R¿3? est hydrogène, hydroxy, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4? ou halogène; R¿4? est hydrogène ou halogène, R¿5? est hydrogène, alcoxy C¿1?-C¿4?, nitro, halogène ou haloalkyle; R¿6? est hydrogène ou nitro; R¿7? est hydrogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4?, nitro ou halogène; R¿8? est hydrogène, hydroxy, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4? ou halogène; R¿9? est hydrogène ou nitro; R¿10? est hydrogène ou halogène; R¿11? est hydrogène, amine C¿1?-C¿4?; R¿12? est hydrogène, alkyle C¿1?-C¿4? ou halogène; R¿13? est hydrogène, amine C¿1?-C¿4?; R¿14? est hydrogène ou halogène; R¿15? est hydrogène, alcoxy C¿1?-C¿4?, haloalkyle C¿1?-C¿4?, nitro ou halogène; R¿16? est hydrogène ou nitro; R¿17? est hydrogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4?, nitro ou halogène; R¿18? est hydrogène, alcoxy C¿1?-C¿4?, hydroxy ou halogène; R¿19? est hydrogène ou nitro; R¿20? est hydrogène ou halogène, et R¿21? est hydrogène ou NO¿2?.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of The Sciences In Philadelphia
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