Novel diazabicyclic aryl derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/08 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 243/00 (2006.01)

Patent

CA 2518675

This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

L'invention concerne des dérivés aryle diazabicycliques se révélant être des ligands cholinergiques sur les récepteurs d'acétylcholine nicotiniques. En raison de leur profil pharmacologique, les composés selon l'invention peuvent servir au traitement de maladies ou de troubles tels que ceux liés au système cholinergique du système nerveux central (SNC), du système nerveux périphérique (SNP), de maladies ou de troubles liés à la contraction de muscles lisses, de maladies ou de troubles endocriniens, de maladies ou de troubles liés à la neurodégénération, de maladies ou de troubles liés à des inflammations, des douleurs et des symptômes de sevrage dus à l'arrêt de l'abus de substances chimiques.

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