Novel dicarbonyl reductase and genes coding for them

Details Novel dicarbonyl reductase and genes coding for them Novel dicarbonyl reductase and genes coding for them

C - Chemistry, Metallurgy

12

N

C12N 9/02 (2006.01) A61K 38/44 (2006.01) C07K 16/40 (2006.01) C12N 15/53 (2006.01)

Patent

CA 2323097

A novel protein having been cloned in mammals for the first time which exerts a dicarbonylreductase activity, has an amino acid sequence showing a homology of about 70 % with a known mouse lung-specific carbonylreductase (CR) and shows a high reductive activity on diacetyl employed as the substrate. This protein is localized around kidney medullary nipples and is expressed specifically in the kidneys. The expression of this protein is significantly reduced in the kidneys of diabetic model mice.

Une nouvelle protéine ayant été clonée dans des mammifères pour la première fois exerce une activité dicarbonylréductase, elle a une séquence d'acides aminés présentant une homologie d'environ 70 % avec une carbonylréductase (CR) connue spécifique des poumons de souris et elle présente une activité réductrice élevée sur le diacétylène employé comme substrat. Cette protéine est localisée autour des mamelons médullaires des reins et elle est exprimée spécifiquement dans les reins. L'expression de cette protéine est réduite de manière significative dans les reins de souris cobayes diabétiques

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