Novel dicarboxylic acid derivatives

Details Novel dicarboxylic acid derivatives Novel dicarboxylic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 229/50 (2006.01) A61K 31/198 (2006.01) A61K 31/223 (2006.01) A61P 9/10 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2411059

2-Amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives represented by the following general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same. These compounds are useful as drugs, in particular, group 2 matabotropic glutamate receptor agonists having therapeutic and preventive effects on, for example, psychiatric diseases such as schizophrenia, anxiety and diseases associating the same, depression and bipolar disorder and neurological diseases such as drug addiction, cognition disorder, Alzheimer's disease, Huntington's chorea, Parkinson's disease, movement disorder associating muscular rigidity, cerebral ischemia, cerebral insufficiency, spinal disorder and head disorder.

L'invention concerne des dérivés d'acide 2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicaboxylique représentés par la formule générale (I) suivante, ainsi que des sels ou des hydrates pharmaceutiquement acceptables de ce composé : (I). Ces composés sont utiles comme médicaments, en particulier comme agonistes du récepteur de glutamate métabotropique du groupe 2 présentant des effets thérapeutiques et préventifs notamment sur des maladies psychiatriques telles que la schizophrénie, l'anxiété et des pathologies associées, la dépression et la maladie affective bipolaire ainsi que sur des maladies neurologiques telles que la toxicomanie, les troubles cognitifs, la maladie d'Alzheimer, la chorée de Huntington, la maladie de Parkinson, des troubles moteurs associés à une rigidité musculaire, l'ischémie cérébrale, l'insuffisance cérébrale, les troubles rachidiens et les céphalées.

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