C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/16 (2006.01) A61K 31/025 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/44 (2006.01) A61P 5/24 (2006.01) C07C 13/48 (2006.01) C07C 39/225 (2006.01) C07C 39/23 (2006.01) C07C 43/20 (2006.01) C07C 43/21 (2006.01) C07D 233/64 (2006.01)
Patent
CA 2298527
Dihydronaphthalene compounds represented by chemical formula (1), which have an excellent 17.alpha.-hydroxylase/C17-20-lyase inhibitory activity, thromboxane A2 synthesis inhibitory activity, and aromatase inhibitory activity and are useful because of these activities as preventives or remedies for various male and female hormone-dependent diseases such as prostatic cancer, prostatic hypertrophy, masculinism, mammary cancer, and mastopathy, myocardial infarct, angina pectoris, and bronchial asthma.
L'invention concerne des composés à base de dihydronaphtalène représentés par la formule chimique (1), ces composés présentant une excellente activité inhibitrice de 17.alpha.-hydroxylase/C¿17-20?-lyase, une activité inhibitrice de la synthèse de thromboxane A¿2?, et une activité inhibitrice d'aromatase. Les composés sont utiles, en raison de ces activités, comme préventifs ou médicaments contre plusieurs affections dépendantes d'hormones mâles ou femelles telles que le cancer de la prostate, l'hypertrophie prostatique, le virilisme, le cancer du sein, la mastopathie, l'infarctus du myocarde, l'angine de poitrine et l'asthme bronchique.
Hartmann Rolf Wolfgang
Ikeda Yoshikazu
Nakakoshi Masamichi
Nomoto Shin
Wachall Bertil
Daiichi Pharmaceutical Co. Ltd.
Sim & Mcburney
Yukijirushi Nyugyo Kabushiki Kaisha
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