C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/023 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) C07K 2/00 (2006.01) C07K 5/00 (2006.01) A61K 38/48 (2006.01) C12N 9/64 (2006.01)
Patent
CA 2737253
The present invention is directed to novel compounds of formula I and pharmaceutically acceptable salts, enantiomers thereof having inhibiting properties of dipeptidyl peptidase IV enzyme (DP-IV inhibitors). The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds along with its composition in the prevention or treatment of diseases associated with DP-IV enzyme. wherein, A is defined as R3-R4 wherein R3 and R4 are together or independently defined as peptides having amino acids ranging from 1 to 10, B is chemical bond between peptide and substituted amine, R1, and R2 are as defined in specification,
Cette invention concerne de nouveaux composés de formule I et des sels pharmaceutiquement acceptables, et énantiomères de ceux-ci ayant des propriétés d'inhibition de l'enzyme dipeptidyl peptidase IV (inhibiteurs de DP-IV). L'invention concerne également des compositions pharmaceutiques les contenant et l'utilisation de ces composés et compositions pour prévenir ou traiter les maladies associées à l'enzyme DP-IV. Dans la formule, A est R3-R4, R3 et R4 étant, ensemble ou indépendamment, des peptides ayant de 1 à 10 acides aminés, B est une liaison chimique entre le peptide et l'amine substituée, R1, et R2 sont tels que définis dans la description.
Chandan Singh
Khamar Bakulesh Mafatlal
Modi Rajiv Indravadan
Borden Ladner Gervais Llp
Cadila Pharmaceuticals Ltd.
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