C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/16 (2006.01) A61K 31/4196 (2006.01) C07D 207/26 (2006.01) C07D 207/32 (2006.01) C07D 209/48 (2006.01) C07D 233/36 (2006.01) C07D 249/08 (2006.01) C07D 257/04 (2006.01) C07D 271/06 (2006.01) C07D 275/02 (2006.01) C07D 277/34 (2006.01) C07D 295/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2682846
The present invention relates to novel compounds representated by formula (I), where R, R1, R2, R3, X, Y, m, n are as defined.The present invention relates to compounds of the general formula I their derivatives, their analogs, their tautomeric forms, their stereoisomers, their diastereomers, their bioisosteres, their polymorphs, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them which are predominantly dipeptidyl peptidase IV inhibitors. The present invention also relates to the processes for the preparation of novel compounds of formula (I) and their use in treating type II diabetes and diabetic complications thereof and also for treating dislipidemia, hypercholesterolemia, obesity and hyperglycemia.
La présente invention concerne de nouveaux composés représentés par la formule (I), dans laquelle R, R1, R2, R3, X, Y, m et n sont tels que définis dans la présente. La présente invention concerne les composés de formule générale (I), leurs dérivés, leurs analogues, leurs formes tautomères, leurs stéréoisomères, leurs diastéréoisomères, leurs bioisostères, leurs polymorphes, leurs sels acceptables du point de vue pharmaceutique et des compositions acceptables du point de vue pharmaceutique contenant ceux-ci, qui sont principalement des inhibiteurs de la dipeptidyl peptidase IV. La présente invention concerne également les procédés pour la préparation des nouveaux composés de formule (I) et l'utilisation de ceux-ci dans le traitement du diabète de type II et de complications diabétiques associées et également pour traiter la dyslipidémie, l'hypercholestérolémie, l'obésité et l'hyperglycémie.
Gopalan Balasubramanian
Ishtiyaque Ahmad
Rasheed Mohammed
Ravi Dhamjewar
Sreedhara Swamy Keshavapura Hosamane
Matrix Laboratories Ltd.
Rogers Law Office
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