Novel dipeptidyl peptidase iv inhibitors used for...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4365 (2006.01) A61K 8/49 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/4353 (2006.01) A61K 31/495 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2542807

The invention relates to medicinally used substances which specifically inhibit peptidases splitting Gly-Pro-p-nitroanilide. The invention further relates to the use of at least one such substance or at least one pharmaceutical or cosmetic composition containing at least one such substance for preventing and treating diseases, particularly diseases with an overshooting immune response (autoimmune diseases, allergies, and transplant rejections), other chronic inflammatory diseases, neuronal diseases, brain damages, skin diseases (acne and psoriasis, among others), tumor diseases, and special viral infections (including SARS).

La présente invention concerne des substances inhibant spécifiquement des peptidases divisant gly-pro-p-nitroanilide, destinées à une utilisation médicale. L'invention concerne également l'utilisation d'une telle substance ou d'au moins une composition pharmaceutique ou cosmétique contenant au moins une telle substance, pour la prophylaxie et le traitement de maladies, notamment de maladies caractérisées par une réponse immunitaire excessive (maladies auto-immunes, allergies et rejets de greffes), d'autres maladies inflammatoires chroniques, de maladies neuronales et de traumatismes cérébraux, de maladies cutanées (par ex. l'acné et le psoriasis), de maladies tumorales et d'infections virales spécifiques (par ex. le SRAS).

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