C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 43/215 (2006.01) A61K 31/05 (2006.01) A61K 31/085 (2006.01) A61K 31/09 (2006.01) A61K 31/192 (2006.01) C07C 39/19 (2006.01) C07C 39/21 (2006.01) C07C 43/23 (2006.01) C07C 59/64 (2006.01)
Patent
CA 2373603
Novel diphenylethylene and styrenes are provided which are administered orally to decrease blood glucose levels in rats. The glucose tolerance in insulin resistant rats is also shown, as well as lowering of triglyceride levels in serum insulin resistant, hyperinsulinemic and hypertriglycedemic rats. The compounds are orally effective anti-diabetic agents that potentially may reduce abnormality of glucose and lipid metabolism in diabetes.
La présente invention concerne de nouveaux diphényléthylène et styrènes qui, en administration orale à des rats, provoquent une baisse de la glycémie. Une tolérance au glucose est également avérée chez les rats insulinodépendants, ainsi qu'une diminution des taux de triglycérides chez les rats résistants à l'insuline sérique, hyperinsulinémiques et hypertriglycéridémiques. Ces composés constituent des anti-diabétiques agissant par voie orale potentiellement capables de réduire les anomalies du métabolisme du glucose et des lipides dans les cas de diabète.
Dey Debendranath
Medicherla Satyanarayana
Nag Bishwajit
Calyx Therapeutics Inc.
Gowan Intellectual Property
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