C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/46 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) C07D 207/34 (2006.01) C07D 207/36 (2006.01) C07D 211/34 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2166075
The present invention relates to an novel dipiperidine derivative represented by formula (1), or a pharmaceutically acceptable salt thereof; Image wherein R1 represents a hydrogen atom or a lower alkyl group; Y represents a single bond or an oxygen atom; n represents 1, 2 or 3; W represents a methylene group or an oxygen atom; R2 represents a hydrogen atom or a carboxyl modifying group which can be eliminated in vivo; X1 and X3 are the same or different and each represents a hydrogen atom or a lower alkyl group. This compound is useful as platelet aggregation inhibitors, cancer metastasis inhibitors, wound remedies or bone resorption inhibitors.
Nouveau dérivé de pipéridine, représenté par la formule générale (I), ou sel pharmaceutiquement acceptable de celui-ci. Dans la formule, R<1> représente hydrogène ou alkyle inférieur; Y représente une liaison simple ou oxygène; n représente 1, 2 ou 3; W représente méthylène ou oxygène; R<2> représente hydrogène ou un groupe carboxyle de modification éliminable in vivo; et X<1>, X<2> et X<3> représentent chacun indépendamment hydrogène, alkyle inférieur ou un autre substituant. Ce composé est utile comme nouvel inhibiteur de l'agrégation plaquettaire, inhibiteur des métastases cancéreuses, cicatrisant ou inhibiteur de la résorption osseuse.
Ikeda Yoshiharu
Kamikawa Yumiko
Nishihara Toshio
Ueki Yasuyuki
Kirby Eades Gale Baker
Sumitomo Pharmaceuticals Co. Ltd.
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