Novel dna, novel protein, and novel antibody

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12N 15/24 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274309

A novel protein capable of activating eosinophile cells; a DNA or oligonucleotides encoding this protein; a recombinant vector containing this DNA; a transformant containing this recombinant vector; a process for producing the above protein by using this transformant; a cell reacting specifically with the above protein; a cell membrane or a receptor binding specifically to the above protein; an agonist or an antagonist to the protein; an antibody binding specifically to the protein; and remedies or diagnostic methods with the use of the same for allergic inflammation, eosinophilic pneumonia, sudden eosinophilia, autoimmune disease, malignant tumor, or vermination.

L'invention concerne une nouvelle protéine capable d'activer les éosinophiles; un ADN ou un oligonucléotide codant pour ladite protéine; un vecteur recombinant contenant ledit ADN; un transformant contenant ledit vecteur recombinant; un procédé permettant de produire ladite protéine à l'aide dudit transformant; une cellule réagissant spécifiquement avec ladite protéine; une membrane cellulaire ou un récepteur liant spécifiquement ladite protéine; un agoniste ou un antagoniste de ladite protéine; un anticorps se fixant spécifiquement sur ladite protéine; ainsi que des médicaments et des méthodes diagnostiques utilisant les éléments ci-dessus et visant les inflammations d'origine allergique, la pneumonie à éosinophiles, l'éosinophilie aiguë, les maladies auto-immunes, les tumeurs malignes et l'infestation par les vers.

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