Novel drug targets for arthritis

Details Novel drug targets for arthritis Novel drug targets for arthritis

A - Human Necessities

61

K

A61K 38/55 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01) G01N 33/68 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2453264

Novel drug targets for the treatment or prevention of arthritis are provided. Screening methods for inhibitors of the plasminogen-activation pathway, such as, for example, antagonists or inhibitors of the urokinase-type okasnubigeb actuvatir (uPA), plasminogen-activator tzpe 1 (PAI-1), the urokinase activator receptor (uPAR), and plasmin, are used to ientify novel drugs for treating or preventing the progression of arthritis. Such screening methods, or methods for evaluating whether a drug is useful for treating or preventing arthritis, can also be conducted in animal models described herein. Methods of treating or preventing such diseases are also provided.

L'invention concerne des nouvelles cibles médicamenteuses destinées au traitement ou à la prévention de l'arthrite. On utilise des méthodes de criblage destinées aux inhibiteurs de la voie d'activation du plasminogène, tels que, par exemple, les antagonistes ou inhibiteurs de l'activateur du plasminogène de type urokinase (uPA), de l'activateur du plasminogène de type 1 (PAI-1), du récepteur de l'activateur de l'urokinase (uPAR), et de la plasmine, en vue d'identifier des nouveaux médicaments destinés à traiter ou prévenir la progression de l'arthrite. Ces méthodes de criblage, qui permettent de déterminer si un médicament est utile pour le traitement ou la prévention de l'arthrite, peuvent également être mises en pratique chez les modèles animaux définis dans la description. L'invention se rapporte en outre à des méthodes de traitement ou de prévention de cette maladie.

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