C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/10 (2006.01) A61K 6/00 (2006.01) C12Q 1/48 (2006.01) G01N 23/20 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2494837
The present invention relates to novel druggable regions discovered in histone H3 lysine methyltransferase DIM-5, which is a SET domain protein. The present invention further relates to methods of using the druggable regions to screen potential candidate therapeutics for diseases in which the activity of SET domain proteins are implicated, for example, anti-cancer/anti-proliferative agents or anti-fungal agents.
L'invention concerne de nouvelles régions accessibles à des médicaments découvertes dans l'histone H3 lysine méthyltransférase DIM-5 qui est une protéine à domaine SET. L'invention concerne également des procédés d'utilisation de ces régions accessibles à des médicaments afin de cribler des agents thérapeutiques candidats potentiels pour des maladies dans lesquelles l'activité de protéines à domaine SET est impliquée, par exemple des agents anticancéreux/antiprolifératifs ou des agents antifongiques.
Cheng Xiaodong
Zhang Xing
Emory University
Mckay-Carey & Company
LandOfFree
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