Novel dual oxidases as mitogenic and endocrine regulators

Details Novel dual oxidases as mitogenic and endocrine regulators Novel dual oxidases as mitogenic and endocrine regulators

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) A61P 3/00 (2006.01) A61P 5/14 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/08 (2006.01) A61P 17/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12N 15/09 (2006.01) C12Q 1/26 (2006.01) C12Q 1/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2409068

The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates and in peroxidative reactions that affect biological functions including cell division, thyroid hormone biosynthesis and tissue fibrosis. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.

La présente invention porte sur de nouveaux gènes codant pour la production de nouvelles protéines impliquées dans la génération d'intermédiaires d'oxygène réactif et dans des réactions peroxydatives qui affectent des fonctions biologiques telles que la division cellulaire, la biosynthèse de l'hormone thyroïdienne et la cirrhose des tissus du foie. La présente invention porte également sur des vecteurs contenant ces gènes, sur des cellules transfectées par ces vecteurs, sur des anticorps contre ces nouvelles protéines, sur des kits de détection, sur la localisation et la mesure de ces gènes et protéines et sur des procédés de détermination de l'activité des médicaments affectant l'activité des protéines de cette invention.

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