Novel ectoparasite saliva proteins and apparatus to collect...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/25 (2006.01) A61K 48/00 (2006.01) C07K 4/12 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) C12Q 1/00 (2006.01) G01N 1/10 (2006.01) G01N 1/24 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2201482

The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating material. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.

L'invention concerne un nouveau produit et un procédé permettant d'isoler des protéines de salive ectoparasites, ainsi que des nouveaux produit et procédé de détection et de traitement d'une dermatite allergique chez un animal. L'invention concerne un appareil de collecte d'une protéine de la salive, pouvant collecter des protéines de salive ectoparasites sensiblement exemptes de matière contaminante. L'invention concerne également des protéines de salive ectoparasites, des molécules d'acide nucléique ayant des séquences qui codent de telles protéines et des anticorps élevés contre de telles protéines. L'invention concerne également des procédés permettant d'obtenir de telles protéines et d'utiliser ces protéines afin d'identifier des animaux susceptibles d'avoir ou ayant une dermatite allergique. L'invention décrit également des compositions thérapeutiques comprenant ces protéines ainsi que leur utilisation pour traiter des animaux pouvant avoir ou ayant une dermatite allergique.

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