Novel elastase inhibitors

Details Novel elastase inhibitors Novel elastase inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) C07K 5/06 (2006.01) C07K 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189527

This invention relates to compounds which are inhibitors of elastase, particularly human neutrophil elastase. The inhibitors are short, synthetic peptides in which the P2 moiety is substituted with various nitrogen- containing heterocyclic groups. As inhibitors of human neutrophil elastase, the compounds are useful in the treatment of a patient afflicted with a neutrophil associated inflammatory disease.

L'invention concerne des composés inhibiteurs d'élastase, en particulier de l'élastase des neutrophiles chez l'homme. Ces inhibiteurs sont de peptides courts synthétiques dans lesquels la fraction P¿2? est substituée par différents groupes hétérocycliques contenant de l'azote. En tant qu'inhibiteurs de l'élastase des neutrophiles chez l'homme, ces composés sont efficaces dans le traitement d'un malade atteint d'une maladie inflammatoire associée aux neutrophiles.

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