C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 11/04 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/66 (2006.01) A61K 35/39 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2214084
The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a crosslinked, mixed functionality, polymer matrix, and methods for their preparation. The encapsulated compositions may comprise the crosslinked polymer matrix layer as an inner layer, an outer layer, or an intermediate layer of an overall encapsulated composition. The compositions will generally also comprise a biological material, e.g., cells, proteins, and the like, encapsulated within the composition. The compositions and methods of the invention are useful in a variety of applications, including cell culturing and transplant therapy.
L'invention porte de façon générale sur de nouveaux procédés et compositions d'encapsulation. Elle concerne en particulier des compositions de microcapsules stabilisées, constituées d'une couche de matrice de polymère réticulé, à fonctionnalité mixte, et les procédés de préparation de celles-ci. Dans ces compositions encapsulées, la couche de matrice de polymère réticulé peut constituer la couche interne, la couche externe, ou une couche intermédiaire d'un ensemble. Les compositions comportent aussi généralement des matériaux biologiques, tels que cellules, protéines et matériaux similaires, encapsulés dans la composition. Les compositions et procédés visés par l'invention ont différentes applications, notamment la culture cellulaire et les thérapies par greffe.
Metabolex Inc.
Sim & Mcburney
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