Novel endoplasmic localization proteins,therapeutic agents...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 31/711 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 11/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2394016

A protein having an activity of regulating glycoprotein production which comprises the amino acid sequence represented by SEQ ID NO:1 in Sequence Listing; variant proteins thereof ; a DNA comprising the nucleotide sequence represented by SEQ ID NO:2 in Sequence Listing; DNA variants thereof; and remedies with the use of the same for diseases associated with glycoprotein abnormality (for example, cystic fibrosis).

L'invention concerne une protéine ayant une activité régulatrice de la production glycoprotéique, contenant la séquence d'acides aminés représentée par SEQ ID NO:1 dans la liste des séquences, des variantes protéiques de cette protéine, un ADN contenant la séquence nucléotidique représentée par SEQ ID NO:2 dans la liste des séquences, des variantes d'ADN de cet ADN, et des remèdes contenant lesdits protéines et ADN destinés au traitement de maladies associées à une anomalie glycoprotéique (par ex. la mucoviscidose).

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