Novel erythromycin derivatives, method of preparation and...

Details Novel erythromycin derivatives, method of preparation and... Novel erythromycin derivatives, method of preparation and...

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/7048 (2006.01)

Patent

CA 2282666

The invention concerns compounds of formula (I) in which A and B form with the atoms to which they are bound a group (a): R1 = NH2, NH-alkyl, NH-alkenyl, NH-alkynyl, (CH2)nAr, NH(CH2)nAr or N=NH(CH2)nAr, Ar = aryl or heteroaryl, optionally substituted; R = H, alkyl optionally substituted, optionally interrupted by one or several heteroatoms, aryl or heteroaryl, optionally substituted, as well as the salts of compounds of formula (I). The compounds of formula (I) have interesting antibiotic properties.

L'invention a pour objet les composés de formule (I) dans lesquels A et B forment avec les atomes auxquels ils sont liés un groupement (a): R1 = NH2, NH-alkyle, NH-alkényle, NH-alkynyle, (CH2)n Ar, NH(CH2)n Ar ou N=CH(CH2)n Ar, Ar = aryle ou hétéroaryle éventuellement substitué; R = H, alkyle éventuellement substitué, éventuellement interrompu par un ou plusieurs hétéroatomes, aryle ou hétéroaryle, éventuellement substitué, ainsi que les sels des composés de formule (I). Les composés de formule (I) présentent d'intéressantes propriétés antibiotiques.

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