Novel ester or amide derivatives

Details Novel ester or amide derivatives Novel ester or amide derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/48 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/4741 (2006.01) A61K 31/519 (2006.01) A61K 31/5383 (2006.01) A61P 31/04 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2419616

Ester or amide derivatives represented by the following general formula (I) which have an antibacterial effect on Helicobacter pylori or pharmaceutically acceptable salts thereof. In particular, ester or amide derivatives of 3-alkyl- 3-oxo-1,4-dihydroquinoline-2-carboxylic acids represented by the following general formulae (I') and (I") or pharmaceutically acceptable salts thereof. In said formula (I), X1 to X4 independently represent each C or N; Y represents O or NH; R1 represents C1 to C6 alkyl; R2 represents C1 to C10 alkyl, etc.; R3 represents hydrogen, C1 to C6 alkyl, etc.; and R4 to R7 are the same or different and each represents hydrogen, halogeno, C1 to C6 alkyl, etc.

L'invention concerne des dérivés estériques ou amidiques, représentés par la formule générale (I), qui ont un effet antibactérien sur Helicobacter pylori, ou des sels pharmaceutiquement acceptables de ces dérivés. Cette invention concerne en particulier des dérivés estériques ou amidiques d'acides 3-alkyl-3-oxo-1,4-dihydroquinoline-2-carboxyliques, représentés par les formules générales (I') et (I''), ou des sels pharmaceutiquement acceptables desdits dérivés. Dans la formule (I), X?1¿ à X?4¿ représentent indépendamment les uns des autres C ou N ; Y représente O ou NH ; R?1¿ représente alkyle C?1¿ à C?6¿ ; R?2¿ représente alkyle C?1¿ à C?10¿, etc. ; R?3¿ représente hydrogène, alkyle C?1¿ à C?6¿, etc. et R?4¿ à R?7¿ sont identiques ou différents et chacun représente hydrogène, halogéno, alkyle C?1¿ à C?6¿, etc.

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