Novel estrogen receptor .beta. and isoforms

Details Novel estrogen receptor .beta. and isoforms Novel estrogen receptor .beta. and isoforms

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) G01N 33/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2298053

The present invention provides the amino acid and nucleotide sequence of the complete estrogen receptor beta (ER.beta.c) gene and related protein sequences. Based on this disclosure, the present invention provides methods for identifying agents that block or augment ER.beta.c mediated transcriptional regulation, methods to determine whether ER.beta.c or its isoforms is being expressed in tissues or cells and methods of identifying and using agents that block the transcriptional regulation of genes by ER.beta.c or its isoforms, which in turn modulates other biological and pathological processes.

La présente invention concerne l'acide aminé et la séquence nucléotidique du gène complet du récepteur bêta d'oestrogène (ER.beta.¿c?) ainsi que les séquences de protéine associées. Au vu de cette découverte, la présente invention concerne des procédés d'identification d'agents bloquant ou augmentant la régulation transcriptionnelle induite par ER.beta.¿c?, des procédés permettant de déterminer si ER.beta.¿c? ou ses isoformes sont exprimés dans des tissus ou des cellules, et des procédés d'identification et d'utilisation des agents bloquant la régulation transcriptionnelle des gènes par ER.beta.¿c? ou ses isoformes, qui, à leur tour, modulent d'autres processus biologiques et pathologiques.

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